Tryptics soy Agar 1,05854

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The life science business of Merck operates as MilliporeSigma in the US and
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SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Version 7.7
Revision Date 30.01.2023
Print Date 31.05.2023
GENERIC EU MSDS – NO COUNTRY SPECIFIC DATA – NO OEL DATA
SECTION 1: Identification of the substance/mixture and of the company/undertaking
1.1 Product identifiers
Product name : Tryptic Soy agar acc. EP, USP, JP, ISO and
FDA-BAM GranuCult®
Product Number : 1.05458
Catalogue No. : 105458
Brand : Millipore
UFI : 1PPX-55VY-899R-Y7HU
REACH No. : This product is a mixture. REACH Registration Number see
section 3.
1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses : Biochemical research/analysis
1.3 Details of the supplier of the safety data sheet
Company : Merck Life Science N.V.
Haarlerbergweg 21 A
1101 CH AMSTERDAM
NETHERLANDS
Telephone : +31 078 620-5411
Fax : +31 078 620-5421
E-mail address : technischeservicebenelux@merckgroup.com
1.4 Emergency telephone
Emergency Phone # : +(31)-858880596 (CHEMTREC)
112 (Alarmnummer)
SECTION 2: Hazards identification
2.1 Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008
Skin sensitization (Category 1), H317
For the full text of the H-Statements mentioned in this Section, see Section 16.
2.2 Label elements
Labelling according Regulation (EC) No 1272/2008
Pictogram
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Signal Word Warning
Hazard statement(s)
H317 May cause an allergic skin reaction.
Precautionary statement(s)
P261 Avoid breathing dust.
P272 Contaminated work clothing should not be allowed out of the
workplace.
P280 Wear protective gloves.
P302 + P352 IF ON SKIN: Wash with plenty of water.
P333 + P313 If skin irritation or rash occurs: Get medical advice/ attention.
P362 + P364 Take off contaminated clothing and wash it before reuse.
Supplemental Hazard
Statements
none
2.3 Other hazards
This substance/mixture contains no components considered to be either persistent,
bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at
levels of 0.1% or higher.
SECTION 3: Composition/information on ingredients
3.2 Mixtures
Component Classification Concentration
Pyruvic acid sodium salt
CAS-No.
EC-No.
Registration
number
113-24-6
204-024-4
01-2120767047-50-
XXXX
Eye Irrit. 2; Skin Sens.
1B; H319, H317
>= 1 – < 10
%
For the full text of the H-Statements mentioned in this Section, see Section 16.
SECTION 4: First aid measures
4.1 Description of first-aid measures
General advice
Show this material safety data sheet to the doctor in attendance.
If inhaled
After inhalation: fresh air.
In case of skin contact
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with
water/ shower. Consult a physician.
In case of eye contact
After eye contact: rinse out with plenty of water. Remove contact lenses.
If swallowed
After swallowing: immediately make victim drink water (two glasses at most). Consult a
physician.
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4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section
2.2) and/or in section 11
4.3 Indication of any immediate medical attention and special treatment needed
No data available
SECTION 5: Firefighting measures
5.1 Extinguishing media
Suitable extinguishing media
Water Foam Carbon dioxide (CO2) Dry powder
Unsuitable extinguishing media
For this substance/mixture no limitations of extinguishing agents are given.
5.2 Special hazards arising from the substance or mixture
Carbon oxides
Hydrogen chloride gas
Sodium oxides
Combustible.
Fire may cause evolution of:
Hydrogen chloride gas
Development of hazardous combustion gases or vapours possible in the event of fire.
5.3 Advice for firefighters
Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by
keeping a safe distance or by wearing suitable protective clothing.
5.4 Further information
Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire
extinguishing water from contaminating surface water or the ground water system.
SECTION 6: Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Avoid inhalation of dusts. Avoid substance contact.
Ensure adequate ventilation. Evacuate the danger area, observe emergency procedures,
consult an expert.
For personal protection see section 8.
6.2 Environmental precautions
Do not let product enter drains.
6.3 Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions
(see sections 7 and 10). Take up dry. Dispose of properly. Clean up affected area. Avoid
generation of dusts.
6.4 Reference to other sections
For disposal see section 13.
SECTION 7: Handling and storage
7.1 Precautions for safe handling
For precautions see section 2.2.
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7.2 Conditions for safe storage, including any incompatibilities
Storage conditions
Tightly closed. Dry.Tightly closed. Dry.
Recommended storage temperature see product label.
Storage class
Storage class (TRGS 510): 11: Combustible Solids
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated
SECTION 8: Exposure controls/personal protection
8.1 Control parameters
Ingredients with workplace control parameters
8.2 Exposure controls
Personal protective equipment
Eye/face protection
Use equipment for eye protection tested and approved under appropriate
government standards such as NIOSH (US) or EN 166(EU). Safety glasses
Skin protection
This recommendation applies only to the product stated in the safety data sheet,
supplied by us and for the designated use. When dissolving in or mixing with other
substances and under conditions deviating from those stated in EN374 please
contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell,
Internet: www.kcl.de).
Full contact
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: > 480 min
Material tested:KCL 741 Dermatril® L
This recommendation applies only to the product stated in the safety data sheet,
supplied by us and for the designated use. When dissolving in or mixing with other
substances and under conditions deviating from those stated in EN374 please
contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell,
Internet: www.kcl.de).
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: > 480 min
Material tested:KCL 741 Dermatril® L
Body Protection
protective clothing
Respiratory protection
required when dusts are generated.
Our recommendations on filtering respiratory protection are based on the following
standards: DIN EN 143, DIN 14387 and other accompanying standards relating to
the used respiratory protection system.
Recommended Filter type: Filter type P2
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The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory
protective devices are carried out according to the instructions of the producer.
These measures have to be properly documented.
Control of environmental exposure
Do not let product enter drains.
SECTION 9: Physical and chemical properties
9.1 Information on basic physical and chemical properties
a) Physical state solid
b) Color beige
c) Odor peptone-like
d) Melting
point/freezing point
No data available
e) Initial boiling point
and boiling range
No data available
f) Flammability (solid,
gas)
No data available
g) Upper/lower
flammability or
explosive limits
No data available
h) Flash point No data available
i) Autoignition
temperature
No data available
j) Decomposition
temperature
No data available
k) pH 7,1 – 7,5 at 40 g/l at 25 °C
(after autoclaving)
l) Viscosity Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
m) Water solubility 40 g/l at 95 °C
n) Partition coefficient:
n-octanol/water
No data available
o) Vapor pressure No data available
p) Density No data available
Relative density No data available
q) Relative vapor
density
No data available
r) Particle
characteristics
No data available
s) Explosive properties Not classified as explosive.
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t) Oxidizing properties none
9.2 Other safety information
Bulk density ca.620 kg/m3
SECTION 10: Stability and reactivity
10.1 Reactivity
The following applies in general to flammable organic substances and mixtures: in
correspondingly fine distribution, when whirled up a dust explosion potential may generally
be assumed.
The following applies in general to flammable organic substances and mixtures: in
correspondingly fine distribution, when whirled up a dust explosion potential may generally
be assumed.
10.2 Chemical stability
The product is chemically stable under standard ambient conditions (room temperature) .
10.3 Possibility of hazardous reactions
Violent reactions possible with:
Strong oxidizing agents
10.4 Conditions to avoid
no information available
no information available
10.5 Incompatible materials
No data available
10.6 Hazardous decomposition products
In the event of fire: see section 5
SECTION 11: Toxicological information
11.1 Information on toxicological effects
Mixture
Acute toxicity
Oral: No data available
Inhalation: No data available
Dermal: No data available
Skin corrosion/irritation
No data available
Serious eye damage/eye irritation
No data available
Respiratory or skin sensitization
Mixture may cause an allergic skin reaction.
Germ cell mutagenicity
No data available
Carcinogenicity
No data available
Reproductive toxicity
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No data available
Specific target organ toxicity – single exposure
No data available
Specific target organ toxicity – repeated exposure
No data available
Aspiration hazard
No data available
11.2 Additional Information
Endocrine disrupting properties
Product:
Assessment : The substance/mixture does not contain
components considered to have endocrine
disrupting properties according to REACH Article
57(f) or Commission Delegated regulation (EU)
2017/2100 or Commission Regulation (EU)
2018/605 at levels of 0.1% or higher.
Hazardous properties cannot be excluded but are unlikely when the product is handled
appropriately.
Components
Pyruvic acid sodium salt
Acute toxicity
Oral: No data available
Inhalation: No data available
Dermal: No data available
Skin corrosion/irritation
Skin – reconstructed human epidermis (RhE)
Result: No skin irritation – 42 min
(OECD Test Guideline 439)
Serious eye damage/eye irritation
Eyes – In vitro study
Result: Causes serious eye irritation. – 6 h
(OECD Test Guideline 492)
Respiratory or skin sensitization
Local lymph node assay (LLNA) – Mouse
Result: positive
(OECD Test Guideline 429)
Germ cell mutagenicity
Test Type: Ames test
Test system: Escherichia coli/Salmonella typhimurium
Result: negative
Species: Rat – male – Red blood cells (erythrocytes)
Result: negative
Remarks: (ECHA)
Carcinogenicity
No data available
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Reproductive toxicity
No data available
Specific target organ toxicity – single exposure
No data available
Specific target organ toxicity – repeated exposure
Aspiration hazard
No data available
SECTION 12: Ecological information
12.1 Toxicity
Mixture
No data available
12.2 Persistence and degradability
No data available
12.3 Bioaccumulative potential
No data available
12.4 Mobility in soil
No data available
12.5 Results of PBT and vPvB assessment
This substance/mixture contains no components considered to be either persistent,
bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at
levels of 0.1% or higher.
12.6 Endocrine disrupting properties
Product:
Assessment : The substance/mixture does not contain components
considered to have endocrine disrupting properties
according to REACH Article 57(f) or Commission
Delegated regulation (EU) 2017/2100 or Commission
Regulation (EU) 2018/605 at levels of 0.1% or higher.
12.7 Other adverse effects
No data available
Components
Pyruvic acid sodium salt
Toxicity to daphnia
and other aquatic
invertebrates
static test EC50 – Daphnia magna (Water flea) – > 100 mg/l –
48 h
(OECD Test Guideline 202)
Toxicity to algae Growth inhibition ErC50 – Raphidocelis subcapitata (freshwater
green alga) – > 3,02 mg/l – 72 h
(OECD Test Guideline 201)
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SECTION 13: Disposal considerations
13.1 Waste treatment methods
Product
See www.retrologistik.com for processes regarding the return of chemicals and
containers, or contact us there if you have further questions.
SECTION 14: Transport information
14.1 UN number
ADR/RID: – IMDG: – IATA: –
14.2 UN proper shipping name
ADR/RID: Not dangerous goods
IMDG: Not dangerous goods
IATA: Not dangerous goods
14.3 Transport hazard class(es)
ADR/RID: – IMDG: – IATA: –
14.4 Packaging group
ADR/RID: – IMDG: – IATA: –
14.5 Environmental hazards
ADR/RID: no IMDG Marine pollutant: no IATA: no
14.6 Special precautions for user
No data available
Further information
Not classified as dangerous in the meaning of transport regulations.
SECTION 15: Regulatory information
15.1 Safety, health and environmental regulations/legislation specific for the
substance or mixture
This material safety data sheet complies with the requirements of Regulation (EC) No.
1907/2006.
Other regulations
Take note of Dir 94/33/EC on the protection of young people at work.
15.2 Chemical Safety Assessment
For this product a chemical safety assessment was not carried out
SECTION 16: Other information
Full text of H-Statements referred to under sections 2 and 3.
H317 May cause an allergic skin reaction.
H319 Causes serious eye irritation.
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Full text of other abbreviations
ADN – European Agreement concerning the International Carriage of Dangerous Goods
by Inland Waterways; ADR – Agreement concerning the International Carriage of
Dangerous Goods by Road; AIIC – Australian Inventory of Industrial Chemicals; ASTM –
American Society for the Testing of Materials; bw – Body weight; CMR – Carcinogen,
Mutagen or Reproductive Toxicant; DIN – Standard of the German Institute for
Standardisation; DSL – Domestic Substances List (Canada); ECx – Concentration
associated with x% response; ELx – Loading rate associated with x% response; EmS –
Emergency Schedule; ENCS – Existing and New Chemical Substances (Japan); ErCx –
Concentration associated with x% growth rate response; GHS – Globally Harmonized
System; GLP – Good Laboratory Practice; IARC – International Agency for Research on
Cancer; IATA – International Air Transport Association; IBC – International Code for the
Construction and Equipment of Ships carrying Dangerous Chemicals in Bulk; IC50 – Half
maximal inhibitory concentration; ICAO – International Civil Aviation Organization;
IECSC – Inventory of Existing Chemical Substances in China; IMDG – International
Maritime Dangerous Goods; IMO – International Maritime Organization; ISHL – Industrial
Safety and Health Law (Japan); ISO – International Organisation for Standardization;
KECI – Korea Existing Chemicals Inventory; LC50 – Lethal Concentration to 50 % of a
test population; LD50 – Lethal Dose to 50% of a test population (Median Lethal Dose);
MARPOL – International Convention for the Prevention of Pollution from Ships; n.o.s. –
Not Otherwise Specified; NO(A)EC – No Observed (Adverse) Effect Concentration;
NO(A)EL – No Observed (Adverse) Effect Level; NOELR – No Observable Effect Loading
Rate; NZIoC – New Zealand Inventory of Chemicals; OECD – Organization for Economic
Co-operation and Development; OPPTS – Office of Chemical Safety and Pollution
Prevention; PBT – Persistent, Bioaccumulative and Toxic substance; PICCS – Philippines
Inventory of Chemicals and Chemical Substances; (Q)SAR – (Quantitative) Structure
Activity Relationship; REACH – Regulation (EC) No 1907/2006 of the European
Parliament and of the Council concerning the Registration, Evaluation, Authorisation and
Restriction of Chemicals; RID – Regulations concerning the International Carriage of
Dangerous Goods by Rail; SADT – Self-Accelerating Decomposition Temperature; SDS –
Safety Data Sheet; TCSI – Taiwan Chemical Substance Inventory; TECI – Thailand
Existing Chemicals Inventory; TSCA – Toxic Substances Control Act (United States); UN
– United Nations; UNRTDG – United Nations Recommendations on the Transport of
Dangerous Goods; vPvB – Very Persistent and Very Bioaccumulative
Classification of the mixture Classification procedure:
Skin Sens.1 H317 Calculation method
Further information
The above information is believed to be correct but does not purport to be all inclusive
and shall be used only as a guide. The information in this document is based on the
present state of our knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any guarantee of the properties of
the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any
damage resulting from handling or from contact with the above product. See
www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional
terms and conditions of sale.
Copyright 2020 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies
for internal use only.
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